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Less is more: progenitor death and cortical size

Cerebral cortex size in individuals and species is determined by cortical progenitor mitosis and death during embryogenesis. EphA signaling—important in axon guidance and patterning—also seems to be critical in regulating the survival of cortex progenitors.

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Figure 1: Radial unit lineage model of cortical neurogenesis.

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Rakic, P. Less is more: progenitor death and cortical size. Nat Neurosci 8, 981–982 (2005). https://doi.org/10.1038/nn0805-981

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