Cerebral cortex size in individuals and species is determined by cortical progenitor mitosis and death during embryogenesis. EphA signaling—important in axon guidance and patterning—also seems to be critical in regulating the survival of cortex progenitors.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Preterm infants with isolated cerebellar hemorrhage show bilateral cortical alterations at term equivalent age
Scientific Reports Open Access 24 March 2020
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Depaepe, V. et al. Nature 435, 1244–1250 (2005).
Rakic, P. Trends Neurosci. 18, 383–388 (1995).
Chenn, A. & Walsh, C.A. Cereb. Cortex 13, 599–606 (2003).
Delalle, I. et al. Cereb. Cortex 9, 824–832 (1999).
Tarui, T. Cereb. Cortex 15, published online 12 January 2005 (10.1093/cercor/bhi017).
Blaschke, A.J., Staley, K. & Chun, J. Development 122, 1165–1174 (1996).
Thomaidou, D., Mione, M.C., Cavanagh, J.F. & Parnavelas, J.G. J. Neurosci. 17, 1075–1085 (1997).
Yang, X. et al. Dev. Biol. 269, 81–94 (2004).
Kuida, K. et al. Nature 384, 368–372 (1996).
Kuida, K. et al. Cell 94, 325–333 (1998).
Haydar, T.F., Kuan, C.-Y., Flavell, R.A. & Rakic, P. Cereb. Cortex 9, 621–626 (1999).
Li, M., Sarkisian, M.R., Mehal, W., Rakic, P. & Flavell, R.A. Science 302, 1560–1563 (2003).
Dufour, A. et al. Neuron 39, 453–465 (2003).
Campbell, D.C. & Holt, C.E. Neuron 37, 939–952 (2003).
Donoghue, M.J. & Rakic, P. Cereb. Cortex 9, 586–600 (1999).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Rakic, P. Less is more: progenitor death and cortical size. Nat Neurosci 8, 981–982 (2005). https://doi.org/10.1038/nn0805-981
Issue Date:
DOI: https://doi.org/10.1038/nn0805-981
This article is cited by
-
Preterm infants with isolated cerebellar hemorrhage show bilateral cortical alterations at term equivalent age
Scientific Reports (2020)
-
Upregulation of MicroRNA miR-9 Is Associated with Microcephaly and Zika Virus Infection in Mice
Molecular Neurobiology (2019)
-
Evolution of the neocortex: a perspective from developmental biology
Nature Reviews Neuroscience (2009)
-
Cell-cycle control and cortical development
Nature Reviews Neuroscience (2007)