Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Less is more: progenitor death and cortical size

Nature Neuroscience volume 8, pages 981–982 (2005)Cite this article

Cerebral cortex size in individuals and species is determined by cortical progenitor mitosis and death during embryogenesis. EphA signaling—important in axon guidance and patterning—also seems to be critical in regulating the survival of cortex progenitors.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Radial unit lineage model of cortical neurogenesis.

References

  1. Depaepe, V. et al. Nature 435, 1244–1250 (2005).

    Article  CAS  PubMed  Google Scholar 

  2. Rakic, P. Trends Neurosci. 18, 383–388 (1995).

    Article  CAS  PubMed  Google Scholar 

  3. Chenn, A. & Walsh, C.A. Cereb. Cortex 13, 599–606 (2003).

    Article  PubMed  Google Scholar 

  4. Delalle, I. et al. Cereb. Cortex 9, 824–832 (1999).

    Article  CAS  PubMed  Google Scholar 

  5. Tarui, T. Cereb. Cortex 15, published online 12 January 2005 (10.1093/cercor/bhi017).

    Google Scholar 

  6. Blaschke, A.J., Staley, K. & Chun, J. Development 122, 1165–1174 (1996).

    CAS  PubMed  Google Scholar 

  7. Thomaidou, D., Mione, M.C., Cavanagh, J.F. & Parnavelas, J.G. J. Neurosci. 17, 1075–1085 (1997).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Yang, X. et al. Dev. Biol. 269, 81–94 (2004).

    Article  CAS  PubMed  Google Scholar 

  9. Kuida, K. et al. Nature 384, 368–372 (1996).

    Article  CAS  PubMed  Google Scholar 

  10. Kuida, K. et al. Cell 94, 325–333 (1998).

    Article  CAS  PubMed  Google Scholar 

  11. Haydar, T.F., Kuan, C.-Y., Flavell, R.A. & Rakic, P. Cereb. Cortex 9, 621–626 (1999).

    Article  CAS  PubMed  Google Scholar 

  12. Li, M., Sarkisian, M.R., Mehal, W., Rakic, P. & Flavell, R.A. Science 302, 1560–1563 (2003).

    Article  CAS  PubMed  Google Scholar 

  13. Dufour, A. et al. Neuron 39, 453–465 (2003).

    Article  CAS  PubMed  Google Scholar 

  14. Campbell, D.C. & Holt, C.E. Neuron 37, 939–952 (2003).

    Article  CAS  PubMed  Google Scholar 

  15. Donoghue, M.J. & Rakic, P. Cereb. Cortex 9, 586–600 (1999).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurobiology and the Kavli Institute for Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, 06511, Connecticut, USA

    Pasko Rakic

Authors
  1. Pasko Rakic
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Rakic, P. Less is more: progenitor death and cortical size. Nat Neurosci 8, 981–982 (2005). https://doi.org/10.1038/nn0805-981

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn0805-981

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing